Online Resources for BioTeach Participants

[as listed in your workshop binder, under " Background Information for BioTeach Labs"]

 

How to get sequence information

 From the National Center for Biotechnology Information (NCBI) at the National Institute of Health (NIH). The NCBI maintains a portal to databases of all known DNA sequences, “GeneBank.” http://www.ncbi.nlm.nih.gov/

 From Genecards, a hyperlinked database correlating DNA and protein sequence information from human genes to literature about diseases.http://www.genecards.org/index.shtml

 

How to process sequence information

 Generate a restriction map from your sequence using NEBcutter (from New England Biolabs, a manufacturer of restriction enzymes) a free online computer program that determines the sites for all known restriction enzymes in a given DNA sequence.  NEB cutter will also give you the translation of your sequence. http://tools.neb.com/NEBcutter/index.php3

 Draw a restricion map for your plasmid using pDRAW, a free downloadable progam. http://medlem.spray.se/acaclone/download/pDRAW32setup.zip

 

Additional Resources

 An excellent website for all things DNA is Dolan DNA Learning Center at Cold Spring Harbor. http://www.dnalc.org  (Pioneers in DNA Science Education; Authors of the Handbook used for the workshop)

Website has different features:

v      DNA Interactive http://www.dnai.org/c/index.html

time line of molecular biology discoveries, lesson planning tools and lesson plans to share for teachers

v      DNA From The Beginning http://www.dnaftb.org/dnaftb/

complete online course in genetics and molecular genetics

v      Geneboy http://www.dnai.org/geneboy/index.html

a neat tool and program for sequence analysis

v      A Library of Biology Animations http://www.dnalc.org/ddnalc/resources/animations.html

 

Animations from Richard Losick, Howard Hughes Medical Institute Professor,

Harvard University

http://www.cfkeep.org/html/snapshot.php?id=41670106

DNA replication

http://www.cfkeep.org/uploads/dna_replication.mov

Translation

http://www.cfkeep.org/uploads/translation.mov

Free Science Education DVDs for the general public from the Howard Hughes Medical Institute (HHMI). http://catalog.hhmi.org/index.jsp

 

About the Human Genome Project: http://www.hhmi.org/biointeractive/genomics/index.html